.

 

Query expression data

The conserved transcriptome in human and rodent male gametogenesis

F. Chalmel, A.D. Rolland, C. Niederhauser-Wiederkehr, S.S.W. Chung, P. Demougin, A. Gattiker, J. Moore, J.-J. Patard, D.J. Wolgemuth, B. Jégou and M. Primig. The conserved transcriptome in human and rodent male gametogenesis. Proc Natl Acad Sci USA, 2007 104: 8346-8351. [PubMed] [Full Text]

Abstract: We report the first cross-species expression profiling analysis of the human, mouse and rat male meiotic transcriptional program, using enriched germ cell populations, whole gonads and high density oligonucleotide microarrays (GeneChips). Among 35% of the protein-coding genes present in rodent and human genomes that were found to be differentially expressed between germ cells and somatic controls, a key group of 357 conserved core loci was identified that displays highly similar meiotic and post-meiotic patterns of transcriptional induction across all three species. Genes known to be important for sexual reproduction are significantly enriched among differentially expressed core loci and a smaller group of conserved genes not detected in 17 non-testicular somatic tissues, correlating transcriptional activation and essential function in the male germline. Some genes implicated in the etiology of cancer are found to be strongly transcribed in testis suggesting that these genes may play unexpected roles in sexual reproduction. Expression profiling data further identified numerous novel conserved genes of biological and clinical interest previously unassociated with the mammalian male germline.

QUERY FORM

Using BioMart

After clicking on QUERY FORM above, select some FILTERS on the next page and then which data you want to EXPORT from the OUTPUT page. At any stage the COUNT button will calculate the number of entries you can expect in the final output.

BioMart can generate a number of different types of output, including sequence and tabulated list data. Multiple output formats, including HTML, text and Microsoft Excel, are also supported.


 

© 2017 Inserm. Hosted by genouest.org. This product includes software developed by Ensembl.

                
GermOnline based on Ensembl release 50 - Jul 2008
HELP